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GTC BIOTHERAPEUTICS TO HOST FIRST QUARTER 2006 EARNINGS CALL AND WEBCAST ON FRIDAY, APRIL 28, 2006

Framingham, Mass., April 21, 2006-- GTC Biotherapeutics, Inc. (Nasdaq: GTCB) ("GTC") announced today that its financial results for the first quarter 2006 will be released on Friday, April 28, 2006 before the Nasdaq market opens. Geoffrey F. Cox, Ph.D., Chairman of the Board, Chief Executive Officer and President, will lead the call on April 28 starting at 10:00 a.m. Eastern Time to discuss these results and the Company's drug development progress. You may access the live internet broadcast or the subsequent archived recording, on GTC's website at http://www.gtc-bio.com or as follows:

Live Call - In the United States, dial 1-800-435-1261
Outside the United States, dial 1-617-614-4076
Reference call ID: when prompted 69634931

Audio Archive - In the United States, dial 1-888-286-8010
Outside the United States, dial 1-617-801-6888
Reference call ID: when prompted 77005214

NOTE: a replay of the call will be available one hour following the end of the call and will be accessible until May 5, 2006.

The earnings webcast is also being distributed over CCBN's Investor Distribution Network to both institutional and individual investors. Individual investors can listen to the call through CCBN's individual investor center at www.earnings.com or by visiting any of the investor sites in CCBN's Individual Investor Network. Institutional investors can access the call via CCBN's password-protected event management site, StreetEvents (www.streetevents.com).

GTC Biotherapeutics is a leader in the development, production, and commercialization of therapeutic proteins through transgenic animal technology. GTC currently has five products in its internal pipeline. GTC's lead program is ATrynŽ, its recombinant form of human antithrombin. In addition to the ATrynŽ program, GTC is developing a recombinant human alpha-1 antitrypsin, a recombinant human albumin, a CD137 antibody to stimulate the immune system as a potential treatment for solid tumors, and a malaria vaccine. GTC also enters into partnering arrangements, or external programs, in which its technology is used to develop transgenic production of its partners' proprietary products, including both large-volume protein therapeutics as well as products that are difficult to produce in significant quantities from conventional recombinant production systems. One of GTC's external programs that is a transgenically produced product is in clinical trials. Additional information is available on the GTC web site, http://www.gtc-bio.com.

CONTACT:
GTC Biotherapeutics, Inc.
Thomas E. Newberry
Vice President, Corporate Communications
(508) 370-5374

Feinstein Kean Healthcare
Francesca DeVellis (investors)
(617) 577-8110



Copyright 2006 GTC Biotherapeutics, All Rights Reserved
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